Small Molecule Inhibitors in Adult High-Grade Glioma: From the Past to the Future - Frontiers
A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors. - Abstract - Europe PMC
Targeting cellular pathways in glioblastoma multiforme | Signal Transduction and Targeted Therapy
A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors. - Abstract - Europe PMC
Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma | Nature Communications
PI3K and Akt as molecular targets for cancer therapy: current clinical outcomes | Acta Pharmacologica Sinica
Cells | Free Full-Text | PI3K/AKT/mTOR-Targeted Therapy for Breast Cancer | HTML
Effects on Cx43, autophagy and the PI3K/Akt/mTOR and MEK/ERK1/2 signal... | Download Scientific Diagram
The effects of PI3K-mediated signalling on glioblastoma cell behaviour | Oncogenesis
Frontiers | Genetic Alterations in Gliomas Remodel the Tumor Immune Microenvironment and Impact Immune-Mediated Therapies
Patient-Derived Orthotopic Xenografts and Cell Lines from Pediatric High-Grade Glioma Recapitulate the Heterogeneity of Histopathology, Molecular Signatures, and Drug Response | bioRxiv
A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a com
Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases | Nature Medicine
Genetic biomarkers of drug response for small-molecule therapeutics targeting the RTK/Ras/PI3K, p53 or Rb pathway in glioblastoma | CNS Oncology
IJMS | Free Full-Text | Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma | HTML
A novel PI3K inhibitor XH30 suppresses orthotopic glioblastoma and brain metastasis in mice models - ScienceDirect
Buparlisib is a brain penetrable pan-PI3K inhibitor | Scientific Reports
PD-L1 confers glioblastoma multiforme malignancy via Ras binding and Ras/Erk/EMT activation - ScienceDirect
Frontiers | Next-Generation in vivo Modeling of Human Cancers
IJMS | Free Full-Text | Molecular Mechanisms of Drug Resistance in Glioblastoma | HTML
A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity - ScienceDirect
Orthotopic GBM model characterization. (A) Tumor cells were isolated... | Download Scientific Diagram
