RCSB PDB - 4O91: Crystal Structure of type II inhibitor NG25 bound to TAK1 -TAB1
Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression. - Abstract - Europe PMC